Effects of Nucleotides and Sugar Nucleotides on Mannosyltransferase Activity in Saccharomyces cerevisiae

Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

Guanylic nucleotide biosynthesis is a conserved and highly regulated process. Drugs reducing GMP synthesis affect the immunological response and mutations enabling guanylic-derivative recycling lead to severe mental retardation. While the effects of decreased GMP synthesis have been well documented, the consequences of GMP overproduction in eukaryotes are poorly understood. In this work, we sel...

Effects of Ferric Nucleotides on Mitochondrial Respiration.

Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15K

Density (r/g cm-3) and viscosity (h/10-2gcm-1s-1=1centipoise,CP) of guanosine monophosphate (GMP) and adenosine triphosphate (ATP) referred to as nucleotide, and 2-deoxy adenosine (DOA) and thymidine (TMD) as nucleoside along with their integral furanose sugar, 2-deoxy ribose (DOR) from 0.0004 to 0.0014mol kg<su...

Influence of dietary nucleotides on growth performance and stress resistance in Kutum (Rutilus kutum Kamenskii, 1901)

A feeding trial has been conducted to evaluate the effects of dietary nucleotide (NT) on growth performance and stress resistance of fry kutum (Rutilus kutum Kamenskii, 1901). A basal diet supplemented with 0 (control), 0.3, 0.5 and 0.7 g NT kg-1 have been formulated for four experimental diets. After 8 weeks of feeding trial, growth parameters were evaluated and then fish has exposed to osmoti...

Saccharomyces cerevisiae Thg1 Uses 5′-Pyrophosphate Removal To Control Addition of Nucleotides to tRNAHis

In eukaryotes, the tRNA(His) guanylyltransferase (Thg1) catalyzes 3'-5' addition of a single guanosine residue to the -1 position (G-1) of tRNA(His), across from a highly conserved adenosine at position 73 (A73). After addition of G-1, Thg1 removes pyrophosphate from the tRNA 5'-end, generating 5'-monophosphorylated G-1-containing tRNA. The presence of the 5'-monophosphorylated G-1 residue is i...